| abstract |
PURPOSE: An antineoplastic agent comprising nontoxic, strongly antitumoral glucan having β-1,6 bond-containing main chain, obtained by extracting Maitake (Grifola) with hot water. n CONSTITUTION: A dry powder of fruit bodies or mycelia of Maitake belonging to Polyporaceae is extracted with hot water. Ethanol is added to the supernatant liquid obtained by centrifuging the extract. Acid-soluble matter is removed from the precipitate, and the alkali-soluble matter is purified to obtain an antineoplastic agent which has a β-1,6 bond-containing main chain of formula I or II and β- 1,3 bond-containing branches in a high frequency, is insoluble in an acid, and soluble in an alkali, and has a MW of 200×10 4 . n EFFECT: It is possible to obtain an antineoplastic agent which is nontoxic when administered in a dose of 10mg/kg day for a month and is nontoxic for an additional 90 days. n COPYRIGHT: (C)1984,JPO&Japio |