| abstract |
NEW MATERIAL:The compound of formula I [R 1 is alkyl; R 2 is H or lower alkyl; X is -C(CO)-O- or -O-C(O)-]. n EXAMPLE: Butoxycarbonylmethyl prostaglandin E 1 ester. n USE: Hypotensor and antithrombotic agent. It can be extremely easily converted to a fat emulsion, and has high ED 50 value. n PREPARATION: The compound of formula I can be prepared by reacting prostaglandin E 1 with the ester compound of formula II (X is halogen, OH or diazo) preferably in the presence of a phase-transfer catalyst [e.g. (CH 3 ) 4 NBr, (CH 3 H 7 ) 4 Nbr, etc.]. The compound has hypotensive and blood platelet coagulation suppressng effect, etc. The conversion of the compound to a fat emulsion is preferably carried out by conventional means using a vegetable oil such as soybean oil, cottonseed oil, etc. Dose: usually 1W100μg for an adult by intravenous injection when used as an antithrombotic agent in the form of a fat emulsion. n COPYRIGHT: (C)1984,JPO&Japio |