| abstract |
NEW MATERIAL:A benzoylpiperazine ester shown by the formula I (A is single bond, alkylene, vinylene, -O-alkylene, or methylene; R is bicyclic carbon ring residue which may be replaced with lower alkyl,lower alkoxy, oxo, nitro or halogen, fluorene residue, fluorenylidene, anthracene residue, phenanthrene residue, with the proviso that a case where A is single bond, R is group shown by the formula II, and R 1 is H or alkoxy is omitted). n EXAMPLE: 1-Isopropyl-4-[4-(9-fluorenylideneacetyloxy)benzoyl] piperazine. n USE: Having an inhibitory action on chymotrypsin, useful, as a drug such as a remedy for pancreatic diseases. n PREPARATION: An carboxylic acid shown by the formula III is reacted with 4- substituted phenyl shown by the formula IV in the presence of dicyclohexylcarbodiimide, to give a compound shown by the formula I . n COPYRIGHT: (C)1984,JPO&Japio |