http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-S5920301-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_afd115dec46c157d3739020ebd4d866b |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08B37-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08B31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-715 |
| filingDate | 1982-07-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8835faba4e60eb92c3d1d92a42e3c8e0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_068c515865c4a6a1774ebb65efec5009 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f80e2fd6e5c573a287a09d521d0149c3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5b8b8639b87c4bc00ee73073c1824e2e |
| publicationDate | 1984-02-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-S5920301-A |
| titleOfInvention | Production of urokinase/dextran derivative |
| abstract | PURPOSE: To obtain the titled derivative in high yields, by gently reducing a specified urokinase/dextran conjugate with a metal cyanoborohydride and further reducing the product with a metal borohydride. n CONSTITUTION: A compound of formula I (wherein P is a dextran residue, and E is a urokinase residue) is reduced gently with sodium cyanoborohydride and then further reduced with sodium borohydride. By this two-stage reduction comprising gentle reduction and subsequent reduction, it is possible to obtain a urokinase/ dextran derivative of formula II in high yields. Here, the compound of formula I can be obtained by reacting dextran with an oxide (e.g., sodium periodate), thereby converting the hydroxyl groups of dextran into aldehyde groups to form activated dextran, and then reacting this activated dextran with urokinase. n COPYRIGHT: (C)1984,JPO&Japio |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0037091-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6632939-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9919364-A1 |
| priorityDate | 1982-07-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 50.