| abstract |
NEW MATERIAL:A compound shown by the formula I [R is 1W4C alkylene, vinylene, or group shown by the formula II(X is H, or lower alkyl)] and its salt. n EXAMPLE: A 5β-(3-carboxypropionyloxy)derivative of milbemycin D. n USE: An acaricide. An insecticide. Showing acaricidal activity especially against Tetranychus, Ixodidae, Dermanysside, and improved insecticidal activity against noxious insects such as flies, lice, cockroaches, etc. and nematodes, etc. n PROCESS: A compound shown by the formula III is reacted with a compound shown by the formula IV in an inert solvent such as n-hexane, ethyl ether, chloroform, etc. in the presence of a base (e.g., triethylamine, pyridine, etc.) at 0W50°C to give a compound shown by the formula I . Milbemycin D shown by the formula III as the starting substance is obtained from a culture of B-41-146 strain belonging to the genus Streptomyces. n COPYRIGHT: (C)1984,JPO&Japio |