| abstract |
PURPOSE: To prepare the titled compound useful as a raw material of an anthelmintics, etc., economically in an industrial scale, by reacting a hydroxyl-substituted amide compound with a halogen-substituted compound in an aprotic polar solvent in the presence of a strongly basic substance. n CONSTITUTION: The compound of formula I or formula II can be prepared by reacting the hydroxyl-substituted amide compound of formula HO-R 1 -CO-NH 2 (R 1 is alkyl, alkenylene, phenylene, etc.) with the halogen-substituted compound of formula R 2 -X (R 2 is alkyl or phenyl-alkyl; X is halogen) in an aprotic polar solvent (e.g. acetonitrile) in the presence of a strongly basic substance (e.g. K 2 CO 3 ) usually at -20W+100°C. n EFFECT: A versatile and inexpensive compound such as lactic acid amide, etc. can be used as the hydroxyl-substituted amide compound, and the objective compound can be prepared easily in high yield. n COPYRIGHT: (C)1984,JPO&Japio |