| abstract |
PURPOSE: The titled base providing a shet pharmaceutical preparation being stuck fast to the gum, capable of being kept in the oral cavity for a long time, releasing a drug gradually, obtained by blending gelatin with gluten, a carboxyvinyl polymer and vinyl acetate resin. n CONSTITUTION: 1W70wt%, especially 5W40wt% gelatin or agar is blended with 1W70wt%, especially 20W38wt% gluten, 1W50wt%, especially 20W30 carboxyvinyl polymer (e.g., polyacrylic acid), and 1W70wt%, especially 12W38wt% vinyl acetate resin or gum (guar gum, natural chicle) based on total amounts of components in the base, respectively. The components are stirred with purified water under heating to give a pasty composition, which is blended with any of various drugs (preferably water-soluble drug) uniformly, and extended and applied to a proper substrate, dried until water content becomes about 0.5W20wt%, to give a sustained release preparation to be applied to the mucosa in the oral cavity. n COPYRIGHT: (C)1984,JPO&Japio |