http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-S59184176-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9483b5a14b1ed8188081ff165e298f1f |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D493-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-535 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D498-04 |
| filingDate | 1983-04-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_423e7e753f0bd9e5248a34f110c9c886 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7ad9acc665e580d6d0178ccf83eb05af |
| publicationDate | 1984-10-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-S59184176-A |
| titleOfInvention | Production of pyrazofurin derivative |
| abstract | PURPOSE: The reaction between 3-(2',3'-5'-O-substituted-β-D-ribofuranosyl)-4-hydroxypyrazol-5-carboxylic acid ester and an amine or a carbonylating agent gives a substituted amide derivative or pyrazolo-cyclized derivative. n CONSTITUTION: The reaction between a compound of formula I (R 1 , R 2 are benzyl or they incorporate to form isopropylidene; R 3 is benzyl, trityl or other protecting group; X is alkoxyl) and a primary or secondary amine such as morpholine or pyrrolidine) is effected by heating to form an amide, then trifluoroacetic acid or boron trichloride is made to act on the amide to effect deprotection to give a compound of formula I where R 1 WR 3 are H and X is substituted amino. Further, a compound of formula I where X is NH 2 is allowed to react with a carbonylating agent such as 1,1'-carbonylimidazole in a nonpolar solvent in the presence of a metal hydride to effect ring closure, followed by deprotection to give a compound of formula II where R 1 WR 3 are H. n USE: Antitumor and antibacterial agent. n COPYRIGHT: (C)1984,JPO&Japio |
| priorityDate | 1983-04-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 30.