http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-S59184132-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a09ca043d7e596facff1f44b746e2f4d http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1374dd16777534b65ad4422333245af8 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-095 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-20 |
| filingDate | 1983-04-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_57e66ae8f6c7de77ca6373762e6919ce http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_513a013e8e57697895be7cc41a745892 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7ea681e2a7ee06159dadc4ddc97244a0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2dbc901c830bef3eef69c3f1e459b06d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_444da9009d1a4d4820eb0fdc14b2fe8e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e71583eb161af79cbbe1ddacafc1691f |
| publicationDate | 1984-10-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-S59184132-A |
| titleOfInvention | Production of pertussis vaccine |
| abstract | PURPOSE: To obtain the titled vaccine on an industrial scale, by cultivating Bordetella pertussis with aeration and agitation under specific conditions, increasing an infection protective antigen HA fraction together with the multiplication of the Bordetella pertussis, and detoxicating the above-mentioned HA fraction in the presence of an amino acid. n CONSTITUTION: Bordetella pertussis is inoculated into a liquid culture medium containing cyclodextrin or a derivative thereof. In the process, the cultivation temperature is kept at 20W37°C, and the amount of dissolved oxygen in the culture medium is kept at 0.7W6ppm. Furthermore, the culture medium is preferably defoamed under conditions of 6<pH<9 for the cultivation with aeration and agitation. The aimed infection protective antigen HA fraction is then collected in the bacterial growth stage in the ogarithmic growth phase or stationary phase and then detoxicated in the presence of an amino acid, e.g. glycine or methionine. The resultant detoxicated HA fraction can be used to produce purified pertussis vaccine, precipitated purified pertussis vaccine, precipitated purified pertussis and diphtheris and tetanus mixed vaccine, etc. economically in large amounts. n COPYRIGHT: (C)1984,JPO&Japio |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-S61271986-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-5207380-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2018007676-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-S6321469-B2 |
| priorityDate | 1983-04-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 27.