| abstract |
NEW MATERIAL:A compound shown by the formula I (X is H, halogen, lower alkyl, lower alkoxy, phenyl, or phenoxy; R is lower alkyl, or 3,4-dihydroxystyryl). n EXAMPLE: 1-(4-Methylphenyl)butan-1-onethiosemicarbazone. n USE: A hypotensor. Having an inhibitory action on decarboxylase. The use of it together with dopa in Parkinson's disease enhances the effect of dopa. n PREPARATION: A ketone shown by the formula II is reacted with thiosemicarbazide in a solvent such as methanol, ethanol, etc. in the presence of an acid catalyst (e.g., acetic acid, hydrochloric acid, etc.) at 40W70°C for 2W24hr to give a compound shown by the formula I . n COPYRIGHT: (C)1984,JPO&Japio |