| abstract |
PURPOSE: The reaction of neocarzinostatin with a styrene-maleic anhydride polymer which contains maleic anhydride residue and half-ester groups and has a specific molecular weight gives the titled complex that is used as a slow- releasing oily carcinostatic preparation with less side-effect. n CONSTITUTION: The objective complex of formula I [n is 1W35 integer; NCS is residue of neocarzinostatin; SMA is residue of half-esterified styrene-maleic acid copolymer containing the groups of formula II and formula III where the maleic group bonds with NCS (where the sum of formulas II and III is more than 1 per 1 molecule and less than 50mol% on the average) and groups of formula IVwhere the maleic acid is half-esterified] is obtained by reaction of neocarzinostatin with a half-esterified styrene-maleic anhydride copolymer of 1,000W10,000 average molecular weight which has 1 or more maleic anhydride groups per one molecule. n COPYRIGHT: (C)1984,JPO&Japio |