| abstract |
PURPOSE: The titled pharmaceutical, obtained by incorporating gelatin soft capsules containing "Nifedipine" therein with capsules obtained by coating the above-mentioned capsules with an enteric substance, having both rapid acting and prolonged release properties, and useful as an antihypertensive agent. n CONSTITUTION: A prolonged release "Nifedipine" pharmaceutical obtained by gelatin soft capsules (preferably spherical capsules having 0.5W5mm diameter and 0.1W100mg weight) containing "Nifedipine" (4-(2'-nitrophenyl)-2,6-dimethyl-3,5- dicarbomethoxy-1,4-dihydropyridine) capable of causing the dilatation of blood vessels by the calcium antagonistic action with prolonged release soft capsules obtained by coating the above-mentioned capsules with an enteric substance, e.g. a carboxyalkyl cellulose derivative, within (1:9)W(9:1) weight ratio range. The capsules without the enteric coating are dissolved in the gastric juice to exhibit rapidly the effect, and the capsules having the coating are subsequently dissolved in the gastric juice to exhibit the prolonged release effect. n COPYRIGHT: (C)1984,JPO&Japio |