| abstract |
PURPOSE:To provide an agent for oral cavity application, containing flavonoid as an active component, suppressing the adhesion of cariogenic bacteria to the flat surface of the teeth, and effective to prevent or inhibit the progress of dental caries. CONSTITUTION:Flavonoid such as rhamnocitrin, kaempferol, etc. is used as a pure substance, or in the form of a vegetable extract containing the same, if necessary in combination with other plaque-formation inhibiting agent or conventional agent for oral cavity application. Flavonoid exhibits the activity to suppress the adhesion of Streptococcus mutans to flat glass surface by in vitro test, and the inhibiting activity to the synthesis of glucan from sucrose by crude glucosyltransferase originated from Streptococcus mutans. |