| abstract |
NEW MATERIAL:The peptide of formula I W formula III (R is H or H-Tyr). n USE: Diagnosis and research of mature T-cell leukemia such as adult T-cell leukemia, T-cell lymphosarcoma cutis, etc., lymphoma, and relating diseases. n PROCESS: The peptide can be prepared according to peptide synthesis process, by condensing the amino acids one by one to the terminal amino acid by acid proccess, chloride process, acid anhydride process, etc. or by coupling the amino acids in several fragments. For example, in the case of solid phase synthesis, the C-terminated amino acid is bonded to an insoluble carrier (e.g. chloromethylated resin) through its carboxyl group, the amino-protecting group is removed, the amino-protected amino acids are bonded by condensation reaction according to the amino acid sequences of formulas I WIII, the peptide is removed from the insoluble carrier after the completion of the synthesis of whole sequence, and if necessary, the protecting groups are removed. n COPYRIGHT: (C)1984,JPO&Japio |