| abstract |
NEW MATERIAL:The compound of formula I [X is lower alkylene chain which may be interrupted with O or S; Y is O or S; n is 0 or 1; Z is phenyl, aminopyridyl, thienyl, furyl, aminothiazolyl, aminothiadiazolyl or aminopyrimidinyl which may have OH group; R 1 is H or CH 2 R 3 (R 3 is H, halogen or OH); R 2 is SO 3 H or OSO 3 H] or its pharmacologically permissible salt. n EXAMPLE: 3S-3-{[(2R, S)-2-(((2R, S)-2-Amino-2-carboxy)ethylthioacetamido)-2-(2- amino-4-thiazolyl)]acetamido}-2-oxo-1-azetidinesulfonic acid sodium salt. n USE: Antibacterial agent. n PROCESS: The compound of formula I can be prepared by acylating the compound of formula II or its salt with the compound of formula III (R 4 and R 5 are protecting group), and eliminating the protecting groups from the product. n COPYRIGHT: (C)1984,JPO&Japio |