| abstract |
NEW MATERIAL:The compound of formula I [R 1 is H or OH-protecting group; R 2 is formyl or group of formula II (R 3 is substitutable alkyl, alkenyl, etc.); Ar is aryl; Y is S or Se; Z is O or carbonyl-protecting group]. n EXAMPLE: 2β-(2'-Methoxyvinyl)-3α-(2'-tetrahydropyranyloxy)-7, 7-ethylenedioxybicyclo[3,3,0]octane. n USE: A synthetic intermediate of carbacycline compound useful as a remedy for thrombosis, etc. n PROCESS: The objective compound of formula I can be prepared by reacting the compound of formula III with the ylide compound of formula IV (R 4 is aryl; R 5 is lower alkyl), and reacting the resultant compound of formula V with the compound of formula Ar-Y-X (e.g. benzene-sulfenyl chloride) in the presence of a base such as NaHCO 3 , Na 2 CO 3 , KHCO 3 , etc. n COPYRIGHT: (C)1984,JPO&Japio |