| abstract |
PURPOSE: A low irritant tiamulin injection obtained by including tiamulin fumarate useful as an antibiotic for animals with α-and/or β-cyclodextrin, having reduced irritation of the drug for animals on tissue. n CONSTITUTION: Fumarate tiamulin shown by the formula useful as a drug for animals, a drug for stock raising, etc. for swine dysentery, swine epidermic pneumonia, etc. is included with α- and/or β-cyclodextrin which is more inexpensively and more easily obtainable than γ-cyclodextrin, to give low-irritant tiamulin injection. The injection is capable of containing not only fumarate tiamulin included with α-cyclodextrin and/or tiamulin fumarate included with β-cyclodextrin, but also tiamulin fumarate included with γ-cyclodextrin, and they all have a molar ratio of tiamulin fumarate to cyclodextrin of 1:(0.1W3). n COPYRIGHT: (C)1984,JPO&Japio |