| abstract |
NEW MATERIAL:A polyprenyl compound of formula I [X is CH=CH, formula I , formula III: Y is formula IV (R 1 is H, lower alkyl); formula V (R 2 is H, lower alkyl)]. n EXAMPLE: 3-[4-(4,8-Dimethyl-1,3,7-nonatrienyl)phenyl]-2-butenoic acid. n USE: Medicine used in prevention or remedy for cancers and precancers, prevention and treatment for epidemic diseases accompanied by keratinization such as acnes or psoriasis, prevention and treatment for inflammatory and allergic dermatoses and prevention and treatment for mucosal diseases caused by inflammation, degeneration, or dysplasic change. n PREPARATION: For example, a compound of formula VI (X is CH=CH, group of formula II, formula III; X is lower alkyl; n is 0, 1) is hydrolyzed to give a compound of formula VII among compounds of formula I . n COPYRIGHT: (C)1983,JPO&Japio |