http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-S58222077-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8ef6ef5fcea57c992721adbad835fdfa |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-08 |
| filingDate | 1982-06-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_404adc2a624f24a13104042494352f17 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_280d0d71011dfcc7220acd1476c124d4 |
| publicationDate | 1983-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-S58222077-A |
| titleOfInvention | Preparation of 1-(4-hydroxyphenyl)-2-(4-benzyl- piperidino)-propan-1-ol tartaric acid salt |
| abstract | PURPOSE: To prepare the titled substance useful as a drug, in high efficiency, by using the novel α-(4-benzylpiperidino)-propionaldehyde as a starting material, reacting the material with 4-benzyloxyphenyl-magnesium halide, and then reacting with hydrogen in the presence of tartaric acid and a catalyst. n CONSTITUTION: The objective compound is prepared by reacting α-(4-benzyl- piperidino)-propionaldehyde with 4-benzyloxyphenylmagnesium halide to obtain 1- (4-benzyloxyphenyl)-2-(4-benzylpiperidino)-propan-1-ol, and reacting the product with hydrogen in the presence of tartaric acid and a reducing catalyst. The novel compound used as the starting material can be synthesized by reacting α- bromopropion-aldehyde acetal with 4-benzylpiperidine, and hydrolyzing the resultant α-(4-benzylpiperidino)-propionaldehyde acetal under acidic condition. n COPYRIGHT: (C)1983,JPO&Japio |
| priorityDate | 1982-06-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 33.