| abstract |
PURPOSE: The titled oil emulsion that is prepared by combining prostaglandin E 1 (PGE 1 ) with an oil emulsifier for intravenous purpose, thus causing no inactivation in lungs and showing vasodilative and hypotensive actions with stabilized effect and less side-effects. n CONSTITUTION: PGE 1 is added to an oil emulsifier consisting of 5W50W/V% of soybean oil, 1W50pts.wt. per 100pts.wt. of soybean oil, of phospholipid and an appropriate amount of water, further emulsification aid, stabilizer and high polymer by 0.2W100μg/ml. The resultant preparation is active about 3 times the PGE 1 -α-cyclodextrin clathrate in vasodilation, about 2W9 times in hypotension and 2W30 times in duration. Further, it shows higher focal selectivity to permit effective treatment. There causes no side-effects such as swelling, dull pains, rubor or fervescence, which oftentimes bring about in local application. n COPYRIGHT: (C)1983,JPO&Japio |