http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-S58216160-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8ef6ef5fcea57c992721adbad835fdfa |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-50 |
| filingDate | 1982-06-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f929aac6476bcf73e9a8698b82522290 |
| publicationDate | 1983-12-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-S58216160-A |
| titleOfInvention | Production of quinoline derivative |
| abstract | PURPOSE: A reaction between a corresponding halogenated starting compound and an alcohol is carried out in an easy-to-handle combination of an aqueous alkali and a hydrophobic organic solvent, in the presence of a salt containing tetraalkylphosphonium ion to give the titled compound. n CONSTITUTION: The reaction between 2-halogeno-N-(2-diethylaminoethyl)cinchonic acid amide of formula II (X is halogen) and n-butyl alcohol is conducted in a combination of an aqueous alkali such as sodium hydroxide or potassium hydroxide and a hydrophobic organic solvent such as chloroform or toluene in the presence of a salt containing tetraalkylphosphonium ion of formula I (R 1 WR 4 are 1W20C alkyl) such as tetrabutylphosphonium chloride or trioctylmethylphosphonium bromide to give a quinoline derivative of formula III. n EFFECT: The process readily results in high yield. n USE: Its hydrochloride is used as a local anesthesia. n COPYRIGHT: (C)1983,JPO&Japio |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106496120-A |
| priorityDate | 1982-06-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 47.