http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-S5799519-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4b18d70d8bf538fb533d0aa5cf87170d |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-00 |
| filingDate | 1980-12-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6dd43cd8d7015f8242b964c1a18f39d5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_92055d66f12dbe95627b0068511b205d |
| publicationDate | 1982-06-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-S5799519-A |
| titleOfInvention | Stable suppository and its preparation |
| abstract | PURPOSE: To obtain a suppository having excellent storage stability and stable drug action and containing two drug components which cause lowering of the drug action by compounding, by dispersing one of the components in oil or fat having specific water-content, and then mixing the dispersion with the other drug component and a substrate. n CONSTITUTION: In the preparation of a suppository containing the A agent such as cloxacillin, oxacillin, cephalexin, etc. and the B agent such as a β-lactam antibiotic substance having α-amino group (e.g. ampicillin, amoxicillin, etc.) which causes lowering of the drug action by compounding, the A agent is dispersed uniformly in an oil or fat having a water-content of ≤0.2wt% (e.g. olive oil, beef tallow, etc.), a substrate composed of a 12W18C saturated fatty acid triglyceride containing monoglyceride and diglyceride is molten by heating and added to the above dispersion, the B agent is uniformly dispersed in the mixture, and the composition is formed to a suppository having a proper shape. The ratio of the A agent to the B agent is pref. 1 to 0.5W2, and the both agents are pref. pulverized to about 30W50μ diameter before mixing. n COPYRIGHT: (C)1982,JPO&Japio |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4525339-A |
| priorityDate | 1980-12-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 32.