http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-S5798298-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_630b360599ea5cf4b5bcbc0c6c0a3e2d |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01J27-22 |
| filingDate | 1980-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2d9e40ae2de6784c1ce22ee8fdcc4a72 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_932d251d76dba73f2f7d4d1810c7f646 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_38670ef1339793e0feb67c054fca5682 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f2e71b2ccb8fac6dbf0139ac76f1dc9e |
| publicationDate | 1982-06-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-S5798298-A |
| titleOfInvention | Preparation of 17beta-ethinylsteroid |
| abstract | PURPOSE: To prepare the titled compound useful as an intermediate for hydrocortisone, prednisolone, etc., economically in an industrial scale, by hydrolyzing 17α-ethinylsteroids using a cuprous salt in place of conventional expensive silver nitrate as a catalyst. n CONSTITUTION: A steroid having the partial structure of formulaI[X is -ONO 2 , -ONO, or OSO 2 R (R is alkyl or aryl)]e.g. 17α-ethinyl-17β-nitroxyandrosta-1, 4-dien-3-one, is hydrolyzed with water in the presence of a coprous salt (e.g. cuprous chloride) pref. at 30W80°C to obtain the objective compound having the partial structure of formula II (e.g. 17β-ethinyl-17α-hydroxyanodrosta-1,4-dien- 3-one). The amount of the cuprous salt is pref, 0.05W0.4 mole per 1 mole of the steroid used as the raw material. n EFFECT: The use of highly toxic sodium cyanide is not necessary. n COPYRIGHT: (C)1982,JPO&Japio |
| priorityDate | 1980-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 30.