http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-S5788196-A

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classificationIPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D249-08
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http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D257-04
filingDate 1980-11-19-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c355ab73b57a1e635c6f6b5d306ebf0a
publicationDate 1982-06-01-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-S5788196-A
titleOfInvention Production of oligonucleotides
abstract PURPOSE: The condensation reaction of nucleotides is effected in the pressence of a specific combination of condensing agents to produce oligopeptides used in gene recombination in high yield. n CONSTITUTION: The condensation reaction between a nucleotide of formulaI(N 1 , N 2 are residue of thymine, N-benzoyldeoxycytosine, N-benzoyldeoxyadenine, N- iso-butyryldeoxyguanine; T is dimethoxytrityl; X is cyanoethyl, P- or o-chlorophenyl, trichloroethyl; m is 0, 1) and another nucleotide of formula II or III (N 3 , N 4 is N 1 ; B is benzoyl, anisoyl; X is Y; n is 0, 1) is conducted in the presence of a combination of (A) mesitylenesulfonyltriazole or triisopropylbenzenesulfonyl nitroimidazole with (B) 1-methylimidazole or 4-dimethylaminopyridine to give the objective compound of formula IV or V. The molar ratio of A:B: the compound of formulaIis (1W4):(2W8):1. n COPYRIGHT: (C)1982,JPO&Japio
isCitedBy http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0415235-A2
priorityDate 1980-11-19-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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