http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-S5772987-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5128cfc84a0fb189fceb3cd240c44493 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-06 |
| filingDate | 1980-10-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c64c0970e75edd82df83d270adb6c17c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8e54540470e27a6ccbb2e43ec51a814f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_db86e55564a7a83dc416272fe23f1d38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_398b0597e6a3aa14a2978b2fdbd9c585 |
| publicationDate | 1982-05-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-S5772987-A |
| titleOfInvention | Production of cephalosporanic acid derivative |
| abstract | PURPOSE: To reaction between 7-aminocephalosporanic acid derivative and a novel active thioester affords a cephalosporanic acid derivative used as an antibiotic with a very wide range of antibiotic spectrum with high safety in high yield. n CONSTITUTION: The reaction of 7-aminocephalosporanic acid derivative of formula I(R 1 is halogen, azide, acetoxy) or its salt with with a 1-methyl-tetrazol-5-ylthiol ester of formula II (R 2 is trifuoromethylthioacetic acid) gives the objective compound of formula III. A new compound of thioester of formula II has a almost the same level of reactivity as an acid chloride or mixed acid anyhdride, which are said to be highest reactive in acylations and effects acylations not only in the 7-position but also in the 3-position. The compound of formula II is obtained from a compound of formula IV and 2-trifluoromethylacetic acid in high yield. n COPYRIGHT: (C)1982,JPO&Japio |
| priorityDate | 1980-10-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
| Predicate | Subject |
|---|---|
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID441328 http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID226457886 |
Total number of triples: 15.