| abstract |
PURPOSE: To prepare the titled compound useful as an intermediate for drugs, in high yield, suppressing the side reactions, by reacting a hydroxyarene with an α,ω- dihalogenoalkane in the presence of an alkali using a tert-alcohol as a solvent. n CONSTITUTION: A tert-alcohol of formula IV (R 2 WR 4 are lower alkyl), e.g. tertbutyl alcohol, is mixed with an alkali such as KOH optionally in the presence of water to obtain a mixture or a solution. A hydroxyarene compound of formulaI(Ar is aryl), e.g. 3,4-methylenedioxyphenol, 5-hydroxyindane, etc., and an α,ω-dihalogenoalkane of formula II (X is halogen; n is integer, pref. 2W6), e.g. 1,2-dibromoethane, and if necessary, an organic solvent, are added to the above mixture or solution, and made to react at 50W150°C for 5minW10hr to obtain the objective compound of formula III, e.g. 1-(2-bromoethoxy)-3,4-methylenedioxybenzene. n COPYRIGHT: (C)1982,JPO&Japio |