| abstract |
NEW MATERIAL:A heptacosapeptide of formula I (Boc is tert-butyloxycarbonyl; Bu t is tert-butyl; OBu t is tert-butyl ester; Tos is tosyl). n USE: A synthetic intermediate for secretin, characterized by the combination of a specific protecting group, and capable of releasing the whole protecting groups readily easily at a low temperature in a short time by using HF and giving secretin of high activity and high purity by a simple purifying method. The secretin is a kind of digestive tract hormone and useful as a pancreatic function testing agent, remedy for the duodenal ulcer, etc. n PROCESS: A decapeptide of formula II is condensed with a heptadecapeptide of formula III to give the heptacosapeptide of formula I. n COPYRIGHT: (C)1982,JPO&Japio |