| abstract |
PURPOSE: A medicine such as ubidecarenone is emulsified by a specific method, then water is removed to produce the objective preparation of high intestinal absorption. n CONSTITUTION: A medicine bearing isoprenoid side chains such as ubidecarenone, menatetrenone or tocopherol nicotinate is dissolved in a hydrophobic organic solvent such as jujube oil. The solution is emulsified in water in the presence of a water- soluble high-molecular substance such as gum arabic and at least the water is evaporated off to give the preparation of fine particles. The resultant preparation is readily redispersible in water due to its fine particles and shows high intestinal absorption, thus being high bioavailability. n COPYRIGHT: (C)1982,JPO&Japio |