http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-S5732299-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_204ea9f0f83d1c51a916e46a41a6a14a |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H15-234 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H15-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7036 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7034 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7028 |
| filingDate | 1980-08-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_92b5dbdbb2968008aeb158620c8ee760 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6cc8c532f23ec9a96265116bf431ba70 |
| publicationDate | 1982-02-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-S5732299-A |
| titleOfInvention | 5-and/or 6"-deoxy derivative of 3'-deoxyamikacin and their preparation |
| abstract | NEW MATERIAL:The compound of formula I (R 1 and R 2 are H or OH; provided that R 1 and R 2 are not OH at the same time) and its acid addition salt. n EXAMPLE: 3',6"-Dideoxyamikacin. n USE: Semi-synthesized aminoglycoside antibiotic substance. n PROCESS: The four amino groups of 3'-deoxyamikacin are protected with amino- protecting groups, the two OH groups at the 4"- and 6"-positions are together protected with one OH-protecting group, and the four OH groups at the 2', 4'-, 2"-, and 2'''- positions are protected with univalent OH-protecting groups, to obtain the compound of formula II [A is H; B is univalent amino-protecting group, etc.; the group of formula III (X and Y are H, alkyl, etc.) is bivalent OH-protecting groups, etc.; D is OH-protecting group of the form of acyl group]. The 4"- and 6"-OH- protecting group is eliminated from the compond of formula II to obtain the compound of formula IV, which is selectively converted to sulfonic acid ester at the 6"- OH, iodized, catalytically reduced to remove the halogen atom, and subjected to the elimination of the remaining OH-protecting group and the amino-protecting group to obtain one of the compounds of formula I wherein R 1 is OH and R 2 is H. n COPYRIGHT: (C)1982,JPO&Japio |
| priorityDate | 1980-08-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
| Predicate | Subject |
|---|---|
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID458397310 |
Total number of triples: 19.