http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-S5732270-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_eea080e03bbd9386a81a90c22aa8bf43 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F7-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-553 |
| filingDate | 1980-08-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aa636d60c41d1e14feb94ef4bc3c5175 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c3520f1a359d8c6fe2b1e5b4d49bd65a |
| publicationDate | 1982-02-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-S5732270-A |
| titleOfInvention | Preparation of 3-substituted-5-halogenated uracil |
| abstract | PURPOSE: To prepare the titled compound, easily, in high yield, by reacting a 5- halogenated uracil with an acrylating agent, reacting the product with a compound such as alkyl halide, and finally removing the 1-position carboxy ester group from the reaction product. n CONSTITUTION: Condensation of the 5-halogenated uracil of formula I (X is halogen, esp. F) with an acylating agent of formula II (R 1 is alkyl or aralkyl; Y 1 is halogen) to obtain the 1-carboxyl ester compond of formula III, which is condensed with the compound of formula IV (R is R 1 , trialkylsilyloxyalkoxyalkyl, tetrahydrofuryl, 5-oxo-2,3,4,5-tetrahydro-2-furyl, etc.; Y 2 is Y 1 ). The objective compound of formula VI can be prepared by removing the 1-position carboxy ester group of the condensation product of formula V, e.g. by hydrolysis with an alkali. n EFFECT: Toxicity, etc. of an antitumor agent, 5-fluorouracil, can be improved. n COPYRIGHT: (C)1982,JPO&Japio |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4528372-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4605738-A |
| priorityDate | 1980-08-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 21.