| abstract |
NEW MATERIAL:A 1-phenylisoquinoline derivative shown by the formulaI(R is H, halogen, or lower alkyl; Y is CH 2 -OR 1 , group shown by the formula II, -CH=NNHCONH 2 , or group shown by the formula III; R 1 is H, lower alkanoyl, organic phosphoric ester residue, with the proviso that the group -CH 2 -Y is linked to the 3-, 4- or 5-position of isoquinoline ring) or its salt. n EXAMPLE: 1-(4-Chlorophenyl)-5-(2-hydroxyethyl)isoquinoline. n USE: Having analgesic and antiphlogistic action, useful as a drug. Having low disorder inducing action on apparatus digestorius. n PROCESS: For example, a compound shown by the formula IV is reacted with a complex metal hydride such as lithium aluminum hydride, etc. in an inert solvent such as ethyl ether, etc. at room temperature W the reflux temperature of the reaction mixture, preferably at 25W60°C, to give a compound shown by the formulaIwhere Y is CH 2 -OR 1 . n COPYRIGHT: (C)1982,JPO&Japio |