| abstract |
NEW MATERIAL:A compound shown by the formulaI[R 1 is H, or lower alkoxy; R 2 is lower alkyl; R 3 is H or ester residue; R 4 is lower alkyl; the bond of wavy line is anti or syn type bond]. n EXAMPLE: (5R, 6R)-Acetoxymethyl 6-( 2-methoxyiminophenetyl )-2-( 1-methyltetrazole-5-yl)thiomethyl-2-penem-3-carboxylate. n USE: An antibacterial agent against Gram-positive and Gram-negative bacteria. n PROCESS: A 6-isocyanopenicillanic acid ester shown by the formula II is reacted with a (2-alkoxyimino)substituted phenetyl halide, reduced, oxidized, subjected to transition reaction, etc., reacted with an alkali metal salt of mercaptotetrazole shown by the formula III (M is alkali metal), and subjected to ring closure reaction, to give a compound shown by the formulaI. n COPYRIGHT: (C)1982,JPO&Japio |