http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-S57193484-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_01156aa8ec92c4b855de0734b6b32407 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D498-08 |
| filingDate | 1981-05-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0cf9d96bab23f219c0f12c7bdea2640c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1b93676cdcec9e289b4210d9210327d5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1f081e0cd986057ed0fb83b1bb1ce5ac |
| publicationDate | 1982-11-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-S57193484-A |
| titleOfInvention | Preparation of rifampicin |
| abstract | PURPOSE: To prepare the titled compound useful as a remedy for tuberculosis, in high yield and purity, by reacting rifamycin S with an oxacyclohexane derivative in the presence of an organic acid, and reacting the product with 1-amino- 4-methyl-piperazine. n CONSTITUTION: Rifamycin S is made to react with 1,3-di-alkyl-1,3-diaza-5-oxacyclohexane of formula (R is alkyl) in a solvent such as dimethylformamide in the presence of an organic acid such as acetic acid, oxalic acid, etc., and the reaction product is made to react with 1-amino-4-methylpiperazine at 50W55°C to obtain the objective compound. In the above process, the production of by-products can be suppressed, the rate of reaction is improved and the yield is increased by keeping the pH of the reaction liquid at 5.5W6.8. n COPYRIGHT: (C)1982,JPO&Japio |
| priorityDate | 1981-05-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 35.