| abstract |
NEW MATERIAL:A compound expressed by the formula[A is 5-W6-membered unsaturated heterocyclic ring or benzimidazolyl containing 1W3 nitrogen atoms (which may be substituted by 1W3 oxo, alkyl, alkoxycarbonyl or halogen); B is =CHR 3 , =C-CR 4 R 5 (R 3 , R 4 and R 5 are H or alkyl); R 1 is alkyl; R 2 is H or alkyl; -N(R 1 )-R 2 is pyrrolidinyl, piperidino, piperazinyl or morpholino; X, Y and Z are H, alkyl, alkoxyl or halogen] or an acid addition salt thereof. n EXAMPLE: 1-[2,4-Dichloro-6-[1-(1-imidazolyl)vinyl]phenoxy]-3-isopropylamino- 2-propanol. n USE: An antiarrhythmic agent. n PROCESS: A compound expressed by formula III as a raw material is reacted with an epihalohydrin, a primary amine or secondary amine one after another to give the compound expressed by formulaI. n COPYRIGHT: (C)1982,JPO&Japio |