| abstract |
NEW MATERIAL:A compound shown by the formulaI(R 1 is H or lower alkyl; R 2 is lower alkyl, amino wherein aryl or phenyl may be substituted, lower alkyl, phenyl, or pyridyl). n EXAMPLE: 2-Amino-4-(o-methoxycarbonylphenyl)carbamoylmethylthiazole. n USE: An antiphlogistic anodyne or antitumor agent. n PROCESS: An o-γ-bromine substituted acetacetamidobenzoic acid shown by the formula II is reacted with a thioamide shown by the formula III in an inert solvent such as methanol, ethanol, chloroform, etc. for tens minutes W several hours at room temperature with stirring or under reflux by heating, to give a compound shown by the formulaI. n COPYRIGHT: (C)1982,JPO&Japio |