| abstract |
PURPOSE: A cream capable of directly being applied to mucosa tissue of the skin, the rectum, the eye, etc., having low stimulation and high safety, obtained by suspending a triglyceride of a middle-chain fatty acid, a carboxyvinyl polymer, and a pharmeceutically active substnace slightly soluble in water as a main agent in purified water. n CONSTITUTION: A cream comprising a pharmaceutically active substance slightly soluble in water, a triglyceride of 6W12C middle-chain fatty acid, purified water and a carboxyvinyl polymer, being adjusted to a pH of 4W10. Preferably 1W 25wt% triglyceride of middle-chain fatty acid is blended with 0.3W3wt% carboxyvinyl polymer and 75W99wt% purified water. Steroids such as fluorometholone, prednisolone, dexamethasone, etc., and nonsteroid antiphlogistics such as indomethacin, ibuprofen, etc. may be cited as the pharmaceutically active substance slightly soluble in water. n COPYRIGHT: (C)1982,JPO&Japio |