http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-S57169480-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_067cda10aaf6d4a5ca8180abe5a545c6 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-43 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-08 |
| filingDate | 1981-04-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_86323401f23d0dbe450350f30e8edb99 |
| publicationDate | 1982-10-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-S57169480-A |
| titleOfInvention | Production of indole derivative |
| abstract | PURPOSE: The reaction between a specific isocyano compound and a specific lithium amide gives the titled derivative used as a synthetic intermediate of β- receptor blocking agent, remedy for arrhythmia and arterial diseases, simply and economically. n CONSTITUTION: For example, a nitrotoluene derivative of formulaI(Z is 5- methyl-3-alkyloxazolidin-2-one residue) is reduced to an amine of formula II and the amine is converted into an isocyano compound of formula III (R is alkyl) such as 5-(2-methyl-3-isocyanophenyl)-oxymethyl-3-isopropyloxazolidin-2-one. The isocyano compound is made to react with lithium amide of formula IV (R 1 is alkyl, aralkyl, aryl) such as Li-diisopropylamide to give the objective compound of formula V such as 5-(4-indolyloxymethyl)-3-isopropyloxazolidin-2-one. n COPYRIGHT: (C)1982,JPO&Japio |
| priorityDate | 1981-04-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 31.