http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-S57169458-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_067cda10aaf6d4a5ca8180abe5a545c6 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-43 |
| filingDate | 1981-04-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_86323401f23d0dbe450350f30e8edb99 |
| publicationDate | 1982-10-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-S57169458-A |
| titleOfInvention | Preparation of indole derivative |
| abstract | PURPOSE: To obtain the titled compound which is a remedy for arrhythmia, etc. advantageously, by the condensation and ring closure of a specific formylamide compound or a reactive derivative thereof as a raw material in the presence of an alkali metallic compound e.g. CH 3 ONa, and neutralizing the resultant product. n CONSTITUTION: A 5-( 2-methyl-3-formylaminophenyl )-oxymethyl-3-alkyloxazolidin-2-one of formula V (Z is 5-methyl-alkyloxazolidin-2-one) or a reactive derivative thereof is subjected to the condensation and ring closure in the presence of a compound of the formula R 1 OM (R 1 is alkyl, aryl or aralkyl; M is alkali metal), and the resultant 5-(4-indolyloxymethyl)-3-alkyloxazolidone-N 1 -alkali metallic salt of formula II' is neutralized with an acid to afford an indole derivative of formula II. The compound of formula II' is further hydrolyzed to afford a 4-(2-hydroxy-3-alkylaminopropoxy)indole derivative of formulaI. n COPYRIGHT: (C)1982,JPO&Japio |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5863935-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5466699-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5399574-A |
| priorityDate | 1981-04-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 25.