http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-S5716900-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5152bcb05bbc271001c0c3b31e8cc3c1 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J9-00 |
| filingDate | 1980-07-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9923149501c73db182080462ec86aabe |
| publicationDate | 1982-01-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-S5716900-A |
| titleOfInvention | Production of (+)-5alpha-dihydropregnenolone |
| abstract | PURPOSE: The reaction of a dodecahydrophenanthrene-2(1H)-one derivative with methyl lithium is followed by reaction of the product with a methyl halide in the presence of a metal amide and cyclization to give the titled compound in high yield through a shortened process. n CONSTITUTION: The reaction of a compound of formula I with methyl lithium is conducted in an organic solvent such as tetrahydrofuran to give an acetylenic alcohol of formula II. The product is made to react with a methyl halide such as methyl iodide in the presence of a metal amide to form a compound of formula III. The cyclization of the compound is effected with a strong acid in a solvent such as a mixture of trifluoroacetic anhydride-trifluoroacetic acid to give (+)-5α-dihydropregnenolone of formula IV. n EFFECT: In the process, the stereoselectivity is significantly kept to give the objective compound. n COPYRIGHT: (C)1982,JPO&Japio |
| priorityDate | 1980-07-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 28.