| abstract |
NEW MATERIAL:The compound of formulaI(R 1 is H or lower alkyl; R 2 is 1W10C alkyl or cycloalkyl; R 3 is H or methyl; R 4 and R 5 are H or protecting group), or when R 1 is H, the non-toxic salt of the acid. n EXAMPLE: 4-Thiaprostaglandin I 1 methyl ester 11,15-bis-t-butyl dimethylsilyl ether. n USE: Useful as a remedy for gastric ulcer, duodenal ulcer and asthma. It has antiulcer and antiasthmatic activity. n PROCESS: The compound of formulaIis prepared by reacting the cyclopentanol derivative of formula II (R 4-1 and R 5-1 are protecting group) with the sulfenyl derivative of formula III (X is Cl, etc.) in an organic solvent at -80W+20°C, and if necessary, eliminating the protecting group and/or hydrolyzing the product. n COPYRIGHT: (C)1982,JPO&Japio |