http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-S57165371-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c999fee6428152a996011d506925c2d7 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-64 |
| filingDate | 1981-04-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ddf87ad6ed4c26b81b4c80f8cf15ba09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8f6e6874fd18c9beec762383db4a66cd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_084f6a5ff20948cac385ef4ed4f22d56 |
| publicationDate | 1982-10-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-S57165371-A |
| titleOfInvention | Preparation of n-acylcarnosine |
| abstract | PURPOSE: To prepare the titled compound useful as a drug, in high yield and purity, by reacting a reactive derivative of 3-acylaminopropionic acid with a histidine ester, and hydrolyzing the resultant N-acylcarnosine ester. n CONSTITUTION: The N-acylcarnosine of formuls IV is prepared by (1) reacting (A) a reactive derivative of 3-acylaminopropionic acid of formulaI(R is alkyl, aryl or aralkyl; X is reactive derivative group of carboxylic acid, e.g. Cl, -O- S(=O) 2 -OH, etc.) obtained by treating 3-acylaminopropionic acid with a proper reagent for activating carboxylic acid, e.g. thionyl chloride, anhydrous sulfuric acid, etc. with (B) a histidine ester of formula II (R" is alkyl, aryl or aralkyl), and (2) hydrolyzing the resultant N-acylcarnosine ester of formula III. n EFFECT: The condensation reagent is also inexpensive and safe. n USE: Drug having strong suppressing effect to the peripheral system of the cerebrum. n COPYRIGHT: (C)1982,JPO&Japio |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105153038-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5503776-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105461632-A |
| priorityDate | 1981-04-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 21.