| abstract |
NEW MATERIAL:The bicyclooctane derivative of formulaI[X 1 is free or esterified carboxyl, hydroxymethyl, cyano, etc.; Y is ethylene or vinylene; R 1 is H or hydroxy; R 2 is H or together with R 1 form a single bond; R 3 is hydroxy; R 4 is H or lower alkyl; R 5 is H, alkenyl, alkynyl, alkyl, lower cycloalkyl, etc.; A is Ch=CH or group of formula II; R 6 and R 7 are H, etc.; m 1 is 1 or 2; m 2 is 0W2; excluding the compound of formula III (Z and Z' are H, etc.; R 8 is H, alkyl, etc.; R 9 is H or lower alkyl)]. n EXAMPLE: 2β-(3'-Hydroxy-trans-1'-octenyl)3α-hydroxy-7-(o-cyanobenzyloxy)-cis-bicyclo-[3,3,0]octane. n USE: Useful as a remedy for ulcer having low side effects. n PROCESS: The compound of formulaIcan be prepared by reacting the compound of formula IV (X 2 is carboxyl, etc.) e.g. with a reducing agent. n COPYRIGHT: (C)1982,JPO&Japio |