| abstract |
NEW MATERIAL:To peptide compound of formualaI(R<1> is heptanoyl, R<2> is benzyl, R<3> is 1-carboxylethylamino, R<4> is carboxy or methoxycarbonyl, n is 0; or R<1> is stearoyl, R<2> is benzyl, R<3> is 1-ethoxycarbonylethylamino, R<4> is ethoxycarbonyl, n is 1; etc.) and its salt. EXAMPLE:Stearoyl-L-alanyl-gamma-D-glutamyl(alpha-OH)-(L)-meso alpha, epsilon-diaminopimelyl-(D)- O-methyl-(L)-D-alanyl 0-methyl. USE:Remedy for infectious diseases. Useful for the remedy of infectious diseases caused by Gram-positive bacteria, Gram-negative bacteria, molds, etc. PROCESS:The compound of formulaIa is prepared by reacting the compound of formula II or its salt with the compound of formula III (Ra<4> is carboxy or methoxycarbonyl) or its salt. |