| abstract |
NEW MATERIAL:A compound of the formula (A is aminoacyl group of a kind of N-acylaminoacid such as N-acyl group-having alanine, phenylalanine, valine, isoleucine, leucine or thyrosine). n EXAMPLE: 5'-O-(N-butyrylvalyl)-5-fluorouridine. n USE: Anti-malignant-tumor agent, antiviral agent or immunosuppressive agent. n PREPARATION: The reaction between a kind of N-acylaminoacid, alanine, phenylalanine, valine, isoleucine, leucine or thyrosine having an acyl group on the N- atom, such as N-benzyloxycarbonyl-valine, and 2', 3'-O-alkylidene-5-fluorouridine is effected in the presence of a condensation reagent such as dicyclohexylcarbodiimide and the product is heated in the presence of an acid such as trifluoroacetic acid to remove the alkylidene group to give the compound of the formula. n COPYRIGHT: (C)1982,JPO&Japio |