| abstract |
NEW MATERIAL:Peptide opioide of formulaI[Tyr is tyrosine; Gly is glycine; Phe is phenylalanine; Leu is leucine residue; R is formula II (Arg is arginine; LyS is lysine; Pro is proline), formula III (Ile is isoleucine) which is connected to the terminal of Leu]. n EXAMPLE: Tyr-Gly-Gly-Phe-Leu-Arg-Lys-Tyr-Pro. n USE: Morphine-like analgesic. n PREPARATION: Pig hypothalamus, after defatted, is extracted with acetic acid to collect the low-molecular fraction. Then, G-fraction is collected from the basic fraction eluted with ammonia as a fraction eluting before α-neo-endorphin and subjected to gel filtration. The eluate is subjected to high-speed liquid chromatography to effect purification and β-neo-endorphin and pH-8P are obtained from the selected two peaks where R is formula II of the formulaIin the former and R is formula III in the latter. n COPYRIGHT: (C)1982,JPO&Japio |