http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-S57130971-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9f2aa9565f6a60fddb5b4a47449ed278 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-43 |
| filingDate | 1981-02-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_de1d83d1bd9dedb580b505f58641f73f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0ea55e3cecbfe54ef2da6e48980ef7f3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9385cb1bc9e4593ec24330f6c5906d45 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d646d65864ba2a1bbb9d42467d7351ef |
| publicationDate | 1982-08-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-S57130971-A |
| titleOfInvention | Preparation of 4-(3-amino-2-hydroxy-propoxy)indole |
| abstract | PURPOSE: To prepare the titled substance by hydrolyzing 4-(2-hydroxy-3-phthalimino-propoxy)indole obtained by the reaction of 4-hydroxyindole with the reaction produce of epichlorohydrin and phthalimide. n CONSTITUTION: The compound of formula III is prepared by (1) reacting epichlorohydrin with phthalimide in a solvent such as water, alcohol, etc. at 40W 100°C pref. in the presence of a basic catalyst such as tri-(n-butyl)amine, etc. to obtain a mixture of the compound of formulaIand formula II, (2) reacting the mixture, without separating into each component, with 4-hydroxyindole in a solvent such as toluene in the presence of an alkali (e.g. potassium carbonate) at 80W160°C, and (3) hydrolyzing the resultant 4-(2-hydroxy-3-phthalimino-propoxy) indole at 90W105°C in the presence of an alkali (e.g. KOH). n USE: Intermediate of pharmaceuticals. n COPYRIGHT: (C)1982,JPO&Japio |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2009185047-A |
| priorityDate | 1981-02-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 41.