http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-S57130969-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_05067da8767942e8e85a838f95f57127 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-43 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-12 |
| filingDate | 1981-02-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4ebf66d0d24474e53d1ca88530b31990 |
| publicationDate | 1982-08-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-S57130969-A |
| titleOfInvention | Preparation of indole derivative |
| abstract | PURPOSE: To prepare the titled compound, easily, in high yield, at a low cost, by reacting inexpensive 4-chloroindole as a starting material with a specific phenyloxazolidine derivative, hydrolyzing the product with dilute mineral acid, and then treating with an alkali. n CONSTITUTION: [(2'-Hydroxy-3'-isopropylamino)propyloxy]-indole of formulaI useful as a remedy for hypotension, tachycardia and premature contraction, is prepared by (1) reacting 4-chloroindole of formula II with S-3-isopropyl-5-hydroxymethyl2-phenyloxazolidine of formula III in the presence of a catalyst (e.g. aliquot crown compound, etc.) in a solvent using a base such as NaOH, (2) hydrolyzing the resultant compound of formula IV with dilute mineral acid to afford the compound of formula V (X is HCl, HNO 3 , or 1/2H 2 SO 4 ), and (3) treating the compound with an alkali (e.g. NaOH, KOH, etc.). n COPYRIGHT: (C)1982,JPO&Japio |
| priorityDate | 1981-02-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 31.