| abstract |
NEW MATERIAL:The validamine derivative of formula (Z is hydroxyl, phenoxy, thienyl, pyridyl, etc.). n EXAMPLE: N-(1,3-Dihydroxy-2-propyl)validamine. n USE: α-Glucosidase inhibiting agent. It has higher α-glucosidase inhibiting activity than validamine. Since the compound suppresses the metabolism of carbohydrates in human and other animals, it is effective to suppress the increase of the blood sugar level, and is useful as pharmaceuticals such as preventives for various diseases caused by hyperglycemia, dental caries, etc. and food additives, feed additives, etc. n PROCESS: The compound of formula is prepared by reducing a Schiff base (asomethine derivative) obtained by the reaction of validamine with a 1W10C chain aldehyde or ketone which may have substituent groups selected from OH, phenoxy, furyl, pyridyl, and cyclohexyl in a proper solvent. n COPYRIGHT: (C)1982,JPO&Japio |