| abstract |
NEW MATERIAL:The phenylcyclohexene derivative of formulaI[R is (lower alkyl)-substituted or aryl-substituted amino (lower alkyl), lower alkanoylamido, or OCOR'; R' is alkyl or (lower alkyl)-substituted amino (lower alkyl)]. n EXAMPLE: 3-dimethylaminomethyl-1-phenylcyclohexene-1. n USE: It has blood platelet coagulation suppressing activity, and is useful as a drug or its intermediate. n PROCESS: For example, the compound of formulaIwherein R is substituted amino (lower alkyl) can be prepared by dehydrating the phenylcyclohexanol of formula II with phosphorus oxychloride in pyridine, thionyl chloride in pyridine, or hydrochloric acid, etc., and the compound wherein R is OCOR' can be obtained by reacting the phenylcyclohexenol of formula III with reactive derivative of an alkanoyl acid. n COPYRIGHT: (C)1982,JPO&Japio |