| abstract |
NEW MATERIAL:A compound shown by the formulaI{X is single bond, or trans-vinylene; R 1 is 6W10C straight-chain alkyl; R 2 is group shown by the formula II[Y is -OR 5 (R 5 is H, 1W5C straight-chain or branched-chain alkyl, etc.)]; R 3 is H, 1W5C straight, branched-chain alkyl}. n EXAMPLE: 4-[4-(cis-1-Decenyl)benzamido]butanoic acid. n USE: An inhibitor against leukotriene biosynthesis. Having inhibiting action on 5- lipoxygenase, controlling leukotriene biosynthesis of mammals including human, useful for remedying and preventing allergic diseases of air tube and bronchus. n PROCESS: A compound shown by the formula III is treated with an alkocycarbonyl chloride and converted into an acid anhydride, which is reacted with a compound shown by the formula IV (m is 1W5), to give the titled compound shown by the formula V[R 21 is group shown by the formula VI]. n COPYRIGHT: (C)1982,JPO&Japio |